Compensatory Increase of Serum Hepassocin Protects Hyperthyroidism-Induced Hepatic Dysfunction

Hepatic dysfunction is commonly observed in subjects with hyperthyroidism. Hepassocin a hepatokine playing an important role metabolic diseases and exhibiting hepatic protective effect. Nevertheless, the relationship between hepassocin hyperthyroidism was still unknown. In present study, total of 36 Graves’ disease were enrolled, we found that alanine aminotransferase (ALT) levels significantly decreased parallel decrement serum concentrations at 6 months after standard treatment for addition, HepG2 cell line used to investigate hyperthyroidism-induced dysfunction. Treatment recombinant protein cells dose-dependently triiodothyronine (T3)-induced ALT aspartate (AST) elevation. Moreover, increased expression phosphoenolpyruvate carboxykinase (PEPCK) dose-dependent manner. Deletion reversed effects T3 on PEPCK expressions. Furthermore, through hepatocyte nuclear factor 1α-dependent pathway. Taken together, these results indicated compensatory increase might have